| Langerhans cell histiocytosis in a newborn. | |
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MedLine Citation:
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PMID: 19948441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A full-term female baby was admitted to our hospital at the postnatal age of 37 days with generalized vesiculopapular, crateriform skin lesions. Physical examination revealed a well-nourished baby without fever, hepatosplenomegaly or lymphadenopathy. Laboratory examination was normal except for thrombocytosis (platelet count, 970 x 10(3)/microL). All studies for herpes simplex virus, including culture, polymerase chain reaction and IgM, were negative except for an antigen test from the vesicles for herpes simplex virus type 1, which was positive. Chest X-ray showed increased reticulogranular infiltration over bilateral lung fields and some osteolytic lesions at the left parietal bone. Skin biopsy revealed infiltration of Langerhans cells and eosinophils, plus positive CD1a and S-100 stains. The diagnosis was reconfirmed by a second hospital and chemotherapy was given. In this case report, the differential diagnoses of neonatal vesiculopapular skin lesions, and the classification and outcome of neonatal Langerhans cell histiocytosis are presented. |
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Authors:
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Tzu-Ying Yang; Shu-Jen Chen; Ling-Yu Yang; Ren-Bin Tang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Chinese Medical Association : JCMA Volume: 72 ISSN: 1728-7731 ISO Abbreviation: J Chin Med Assoc Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-01 Completed Date: 2010-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101174817 Medline TA: J Chin Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 611-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Diagnosis, Differential Female Histiocytosis, Langerhans-Cell / diagnosis*, drug therapy, pathology Humans Infant, Newborn Skin / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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