Document Detail

Langerhans cell histiocytosis arising from a BCC: a case report and review of the literature.
MedLine Citation:
PMID:  20666189     Owner:  NLM     Status:  MEDLINE    
Langerhans cell histiocytosis (LCH) is a rare disease characterized by a proliferation of Langerhans cells. Several organs may be involved, including the skin, bone, and central nervous system. Adult onset of LCH and solely localized cutaneous involvement are quite uncommon. Langerhans cell histiocytosis has been found in combination with other skin lesions and systemic conditions, but no definitive conclusion exists for this phenomenon. We present a case report of a 63-year-old woman who initially presented with 3 pink papules on her forehead that had developed sequentially within 1 month, all diagnosed by biopsy as basal cell carcinoma (BCC) and appropriately treated. Concurrent with the appearance of the third BCC, the patient began developing crusted ulcerative nodules on her scalp. Biopsy of 1 scalp nodule revealed a BCC, but a repeat biopsy of the same nodule weeks later revealed LCH. Langerhans cell histiocytosis arising from a BCC is extremely rare. No absolute explanation exists regarding the transformation of a BCC into LCH, but understanding the behavior of Langerhans cells may give us better insight into how this process could occur.
Payal Patel; Rakhshandra Talpur; Madeleine Duvic
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  85     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-08-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
University Hospitals Richmond Medical Center, Richmond Heights, Ohio, USA.
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MeSH Terms
Carcinoma, Basal Cell / complications*,  pathology
Histiocytosis, Langerhans-Cell / diagnosis*,  etiology,  pathology
Langerhans Cells / pathology
Middle Aged
Scalp / pathology
Skin Neoplasms / complications*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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