| The contribution of Langerhans cells to cutaneous malignancy. | |
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MedLine Citation:
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PMID: 21071271 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The skin is at the forefront of environmental exposures, such as ultraviolet radiation and a myriad of chemicals, and is at risk for malignant transformation. The skin is a highly responsive immunological organ that contains a unique population of immature intraepidermal dendritic cells (DCs) called Langerhans cells (LCs). Although LCs show morphological and migratory changes in response to epidermal perturbation, and can function as antigen-presenting cells to activate T cells, their role in carcinogenesis is unknown. Here we review recent studies that have provided clues to the potential roles that LCs might play in the pathogenesis of skin cancer, beyond their stimulation or regulation of adaptive immunity. Understanding this role of LCs might provide new perspectives on the relevance of DC populations that are resident within other epithelial tissues for cancer. |
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Authors:
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Julia Lewis; Renata Filler; Debra A Smith; Kseniya Golubets; Michael Girardi |
Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: Trends in immunology Volume: 31 ISSN: 1471-4981 ISO Abbreviation: Trends Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 460-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06511, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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