| Landiolol reduces coronary artery motion in an open-chest porcine model: implications for off-pump coronary artery bypass surgery. | |
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MedLine Citation:
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PMID: 22105530 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Reduction of target coronary artery motion is imperative for successful off-pump coronary artery bypass surgery. We hypothesized that landiolol, a novel ultra-short-acting selective β-1 blocker, would reduce such coronary artery motion. To test this hypothesis, the motion of the left anterior descending artery of the porcine heart (n = 8) was analyzed by three-dimensional digital motion capture and reconstruction technology with or without continuous landiolol infusion. Landiolol (0.12 mg/kg/min) significantly decreased the heart rate (105 ± 16 vs. 90 ± 9 beats/min), three-dimensional distance moved (-20.4% vs. control), maximum velocity (-30.0% vs. control), acceleration (-31.1% vs. control), and deceleration (-28.6% vs. control) without inducing a significant change in the systolic blood pressure (85 ± 18 vs. 81 ± 22 mmHg), cardiac output (4.3 ± 1.4 vs. 4.1 ± 1.3 l/min), or pulmonary wedge pressure (7.8 ± 3.0 vs. 8.7 ± 2.9 mmHg). Landiolol reduces the heart rate and coronary artery motion with stable hemodynamics, which may facilitate performing precise anastomosis on the beating heart. |
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Authors:
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Hiroki Wakamatsu; Toshiki Watanabe; Yoshiyuki Sato; Shinya Takase; Sadao Omata; Hitoshi Yokoyama |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: Surgery today Volume: - ISSN: 1436-2813 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiovascular Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan, fukushima.cvsurg@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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