Document Detail


Lamprey Variable Lymphocyte Receptors Mediate Complement-Dependent Cytotoxicity.
MedLine Citation:
PMID:  23293356     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An alternative adaptive-immune system is present in the most basal vertebrates-lampreys and hagfish-the only surviving jawless vertebrates. These eel-like fish use leucine-rich repeat-based receptors for Ag recognition instead of the Ig-based receptors used in jawed vertebrates. We report that in Japanese lamprey (Lampetra japonica), variable lymphocyte receptor (VLR)B interacts with C1q and C3 proteins to mediate complement-dependent cytotoxicity for bacteria and tumor cells. The immune-based lysis involves deposition of VLRB and C1q-like protein complex on the surface of target cells, activation of C3, and ultimate disruption of cell wall integrity. The demonstration of functional interaction between VLRB and complement components in lamprey provides evidence for the emergence of cooperative innate and adaptive-immune responses at a pivotal point in vertebrate evolution, before or in parallel with the evolution of Ig-based Abs and the classical complement-activation pathway.
Authors:
Fenfang Wu; Liyong Chen; Xin Liu; Huaying Wang; Peng Su; Yinglun Han; Bo Feng; Xu Qiao; Jing Zhao; Ning Ma; Huijie Liu; Zhen Zheng; Qingwei Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  -     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
College of Life Science, Liaoning Normal University, Dalian, Liaoning 116029, China.
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