Document Detail


Lamotrigine in motor and mood symptoms of Huntington's disease.
MedLine Citation:
PMID:  17853293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by midlife onset, progressive course and a combination of motor, cognitive and psychiatric symptoms. Since dysregulation of the glutamate/calcium signalling pathway is beginning to emerge as a potential cause of neuron degeneration, antagonists of glutamate pathways such as lamotrigine, may have beneficial value for treatment of HD. We describe the use of lamotrigine in the treatment of an HD patient with motor abnormality (choreoathetoidic movements) complicated by psychiatric abnormalities (depression, severe mood swing and recurrent high risk of suicidal attempts). The patient's depression, severe mood swing and choreoathetoidic movements significantly improved with 300 mg/day of lamotrigine. Experience from our patient suggests that lamotrigine might be effective in treating HD patients with motor and mood symptoms. Further controlled studies are warranted to confirm its efficacy in patients of this type.
Authors:
Yu-Chih Shen
Related Documents :
21120833 - Thyroid storm in a patient with fulminant hepatic failure.
16703793 - Comparison of the non-invasive methods estimating dry weight in hemodialysis patients.
13003 - A comparison of flexible and nonflexible plastic cannulae for performing first trimeste...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  9     ISSN:  1562-2975     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-09-26     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC. shengmp@so-net.net.tw
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antimanic Agents / therapeutic use*
Atrophy / pathology
Caudate Nucleus / pathology
Cerebral Cortex / pathology
Chorea / drug therapy*,  etiology*
Female
Humans
Huntington Disease / complications*
Magnetic Resonance Imaging
Middle Aged
Mood Disorders / drug therapy*,  etiology*
Triazines / therapeutic use*
Chemical
Reg. No./Substance:
0/Antimanic Agents; 0/Triazines; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sleep-EEG patterns of school children suffering from symptoms of depression compared to healthy cont...
Next Document:  Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophre...