Document Detail

Lamotrigine in motor and mood symptoms of Huntington's disease.
MedLine Citation:
PMID:  17853293     Owner:  NLM     Status:  MEDLINE    
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by midlife onset, progressive course and a combination of motor, cognitive and psychiatric symptoms. Since dysregulation of the glutamate/calcium signalling pathway is beginning to emerge as a potential cause of neuron degeneration, antagonists of glutamate pathways such as lamotrigine, may have beneficial value for treatment of HD. We describe the use of lamotrigine in the treatment of an HD patient with motor abnormality (choreoathetoidic movements) complicated by psychiatric abnormalities (depression, severe mood swing and recurrent high risk of suicidal attempts). The patient's depression, severe mood swing and choreoathetoidic movements significantly improved with 300 mg/day of lamotrigine. Experience from our patient suggests that lamotrigine might be effective in treating HD patients with motor and mood symptoms. Further controlled studies are warranted to confirm its efficacy in patients of this type.
Yu-Chih Shen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  9     ISSN:  1562-2975     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-09-26     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC.
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MeSH Terms
Antimanic Agents / therapeutic use*
Atrophy / pathology
Caudate Nucleus / pathology
Cerebral Cortex / pathology
Chorea / drug therapy*,  etiology*
Huntington Disease / complications*
Magnetic Resonance Imaging
Middle Aged
Mood Disorders / drug therapy*,  etiology*
Triazines / therapeutic use*
Reg. No./Substance:
0/Antimanic Agents; 0/Triazines; U3H27498KS/lamotrigine

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