Document Detail


Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis.
MedLine Citation:
PMID:  22654459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 69-year-old man was admitted to our hospital in October 2003, for further examination of two liver tumors. He was diagnosed with hepatocellular carcinoma (HCC) arising from decompensated hepatitis B virus (HBV)-related cirrhosis. Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC. His Child-Pugh score was 9 points at start of lamivudine treatment, improving to 5 points after 1 year. His indocyanine green at 15 min after injection test score was 48% before lamivudine treatment, improving to 22% after 2 years and to 5% after 4 years. Radiofrequency ablation controlled the HCC foci and maintained his liver function. In April 2009, abdominal computed tomography revealed a tumor thrombus in the right portal vein. Since his indocyanine green test results had improved to less than 10%, we performed a right hepatectomy, which was successful. To our knowledge, there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis. The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC.
Authors:
Koichi Honda; Masataka Seike; Shin-ichiro Maehara; Koichiro Tahara; Hideaki Anai; Akira Moriuchi; Toyokichi Muro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-01     Completed Date:  2012-12-07     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2586-90     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Oita University, Oita 879-5593, Japan. hondak@oita-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Hepatocellular / physiopathology,  surgery*,  virology
Hepatectomy
Hepatitis B, Chronic / complications,  drug therapy*,  physiopathology
Humans
Lamivudine / therapeutic use*
Liver Cirrhosis / physiopathology,  virology
Liver Neoplasms / physiopathology,  surgery*,  virology
Male
Reverse Transcriptase Inhibitors / therapeutic use*
Chemical
Reg. No./Substance:
0/Reverse Transcriptase Inhibitors; 134678-17-4/Lamivudine
Comments/Corrections

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