| Lamins in development, tissue maintenance and stress. | |
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MedLine Citation:
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PMID: 23146893 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lamins are nuclear intermediate filament proteins. They provide mechanical stability, organize chromatin and regulate transcription, replication, nuclear assembly and nuclear positioning. Recent studies provide new insights into the role of lamins in development, differentiation and tissue response to mechanical, reactive oxygen species and thermal stresses. These studies also propose the existence of separate filament networks for A- and B-type lamins and identify new roles for the different networks. Furthermore, they show changes in lamin composition in different cell types, propose explanations for the more than 14 distinct human diseases caused by lamin A and lamin C mutations and propose a role for lamin B1 in these diseases. |
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Authors:
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Noam Zuela; Daniel Z Bar; Yosef Gruenbaum |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-13 |
Journal Detail:
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Title: EMBO reports Volume: - ISSN: 1469-3178 ISO Abbreviation: EMBO Rep. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963049 Medline TA: EMBO Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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