Document Detail

Lamins in development, tissue maintenance and stress.
MedLine Citation:
PMID:  23146893     Owner:  NLM     Status:  MEDLINE    
Lamins are nuclear intermediate filament proteins. They provide mechanical stability, organize chromatin and regulate transcription, replication, nuclear assembly and nuclear positioning. Recent studies provide new insights into the role of lamins in development, differentiation and tissue response to mechanical, reactive oxygen species and thermal stresses. These studies also propose the existence of separate filament networks for A- and B-type lamins and identify new roles for the different networks. Furthermore, they show changes in lamin composition in different cell types, propose explanations for the more than 14 distinct human diseases caused by lamin A and lamin C mutations and propose a role for lamin B1 in these diseases.
Noam Zuela; Daniel Z Bar; Yosef Gruenbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-13
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-30     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  1070-8     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / genetics
Chromatin / genetics,  metabolism
DNA Replication / genetics*
Lamin Type A* / genetics,  metabolism
Lamin Type B* / genetics,  metabolism
Nuclear Envelope / genetics,  metabolism
Stress, Physiological / genetics
Transcription, Genetic
Reg. No./Substance:
0/Chromatin; 0/Lamin Type A; 0/Lamin Type B; 0/lamin B1; 0/lamin C

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