Document Detail


Laminin alpha2 deficiency-associated muscular dystrophy in a Maine coon cat.
MedLine Citation:
PMID:  14692554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A European case of laminin alpha2 deficiency-associated muscular dystrophy in a 12-month-old, female Maine coon pedigree cat is reported. The history and eventual clinical presentation of this cat differed from those of two cats reported in the USA. In this case, the myopathy was characterised by progressively worsening weakness, muscle atrophy and joint contracture. Tendon reflexes were diminished, and motor nerve conduction velocities were slowed. Muscle biopsy demonstrated a dystrophic phenotype with endomysial fibrosis. Occasional thinly myelinated nerve fibres were present within a peripheral nerve specimen. Poorly myelinated fibres were also found at the root level on necropsy specimens. Immunohistochemical staining revealed the absence of laminin alpha2. The cat's family history did not indicate genetic transmission of the disease.
Authors:
L Poncelet; A Résibois; E Engvall; G D Shelton
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  44     ISSN:  0022-4510     ISO Abbreviation:  J Small Anim Pract     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-24     Completed Date:  2004-01-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-2     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Embryology, Faculty of Medicine, Free University of Brussels, route de Lennik 808, B-1070 Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biopsy
Cat Diseases / diagnosis*,  genetics,  pathology
Cats
Diagnosis, Differential
Female
Laminin / deficiency*
Muscle, Skeletal / pathology
Muscular Atrophy / etiology,  veterinary
Muscular Dystrophy, Animal / complications,  diagnosis*,  genetics,  pathology
Pedigree
Chemical
Reg. No./Substance:
0/Laminin; 0/laminin alpha 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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