| Lambert-eaton myasthenic syndrome; pathogenesis, diagnosis, and therapy. | |
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MedLine Citation:
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PMID: 21969911 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare disease with a well-characterized pathogenesis. In 50% of the patients, LEMS is a paraneoplastic manifestation and caused by a small cell lung carcinoma (SCLC). Both LEMS patients with SCLC and those without this tumour have in 85% of cases pathogenetic antibodies of very high LEMS specificity against voltage-gated calcium channels (VGCCs) in the cell membrane of the presynaptic motor nerve terminal. Better understanding of LEMS pathogenesis has lead to targeted symptomatic therapy aimed at the neuromuscular junction and to semispecific immuno-suppression. For SCLC LEMS, tumour therapy is essential. |
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Authors:
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Nils Erik Gilhus |
Publication Detail:
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Type: Journal Article Date: 2011-09-29 |
Journal Detail:
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Title: Autoimmune diseases Volume: 2011 ISSN: 2090-0430 ISO Abbreviation: Autoimmune Dis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-04 Completed Date: 2011-11-10 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101546750 Medline TA: Autoimmune Dis Country: United States |
Other Details:
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Languages: eng Pagination: 973808 Citation Subset: - |
Affiliation:
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Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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