| Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. | |
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MedLine Citation:
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PMID: 22094130 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular autoimmune disease that has served as a model for autoimmunity and tumour immunology. In LEMS, the characteristic muscle weakness is thought to be caused by pathogenic autoantibodies directed against voltage-gated calcium channels (VGCC) present on the presynaptic nerve terminal. Half of patients with LEMS have an associated tumour, small-cell lung carcinoma (SCLC), which also expresses functional VGCC. Knowledge of this association led to the discovery of a wide range of paraneoplastic and non-tumour-related neurological disorders of the peripheral and central nervous systems. Detailed clinical studies have improved our diagnostic skills and knowledge of the pathophysiological mechanisms and association of LEMS with SCLC, and have helped with the development of a protocol for early tumour detection. |
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Authors:
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Maarten J Titulaer; Bethan Lang; Jan Jgm Verschuuren |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet neurology Volume: 10 ISSN: 1474-4465 ISO Abbreviation: Lancet Neurol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1098-107 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, Leiden University Medical Center, Leiden, Netherlands; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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