Document Detail


Lafora's-like disease in a fennec fox (Vulpes zerda).
MedLine Citation:
PMID:  20945656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 6-yr-old captive-born female fennec fox (Vulpes zerda) had a history of multiple seizures and was treated with diazepam and phenobarbital therapy. Despite medical treatment, the seizures continued. They were intermittent and progressive, resulting in neurologic deficits and death of the animal within 6 mo of onset of the clinical signs. At necropsy, the animal was in good nutritional condition, and no gross lesions were noted in the brain. Histologically, amphophilic to basophilic, periodic acid-Schiff (PAS) positive, diastase-resistant inclusions were present in the brain, heart, and liver. Ultrastructurally, the inclusions were variably electron dense, fibrillary to occasionally granular, and non-membrane bound. The clinical, histologic, and ultrastructural findings were consistent with Lafora's disease, which in humans is a rare, fatal, autosomal recessive hereditary neurometabolic disorder characterized by progressive myoclonic epilepsy. This is the first report of Lafora's-like disease in a fennec fox.
Authors:
Shelley P Honnold; F Yvonne Schulman; Karen Bauman; Kevin Nelson
Related Documents :
1329416 - Pott's tuberculous spondylitis in belgium 1990.
18837096 - Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of c...
9795536 - Lhermitte-duclos disease: first report in taiwan.
22469536 - Vector blood meals and chagas disease transmission potential, united states.
1329416 - Pott's tuberculous spondylitis in belgium 1990.
20808546 - Cyclooxygenase and neuroinflammation in parkinson's disease neurodegeneration.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians     Volume:  41     ISSN:  1042-7260     ISO Abbreviation:  J. Zoo Wildl. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915208     Medline TA:  J Zoo Wildl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Building 54, Room G117, Washington, DC 20306, USA. shelley.honnold@us.army.mil
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Fatal Outcome
Female
Foxes*
Lafora Disease / pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Staphylococcus aureus mastitis in a white-eared opossum (Didelphis albiventris) in the Atlantic Fore...
Next Document:  Application of the laryngeal mask airway for anesthesia in three chimpanzees and one gibbon.