Document Detail

Lafora's-like disease in a fennec fox (Vulpes zerda).
MedLine Citation:
PMID:  20945656     Owner:  NLM     Status:  MEDLINE    
A 6-yr-old captive-born female fennec fox (Vulpes zerda) had a history of multiple seizures and was treated with diazepam and phenobarbital therapy. Despite medical treatment, the seizures continued. They were intermittent and progressive, resulting in neurologic deficits and death of the animal within 6 mo of onset of the clinical signs. At necropsy, the animal was in good nutritional condition, and no gross lesions were noted in the brain. Histologically, amphophilic to basophilic, periodic acid-Schiff (PAS) positive, diastase-resistant inclusions were present in the brain, heart, and liver. Ultrastructurally, the inclusions were variably electron dense, fibrillary to occasionally granular, and non-membrane bound. The clinical, histologic, and ultrastructural findings were consistent with Lafora's disease, which in humans is a rare, fatal, autosomal recessive hereditary neurometabolic disorder characterized by progressive myoclonic epilepsy. This is the first report of Lafora's-like disease in a fennec fox.
Shelley P Honnold; F Yvonne Schulman; Karen Bauman; Kevin Nelson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians     Volume:  41     ISSN:  1042-7260     ISO Abbreviation:  J. Zoo Wildl. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915208     Medline TA:  J Zoo Wildl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Building 54, Room G117, Washington, DC 20306, USA.
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MeSH Terms
Fatal Outcome
Lafora Disease / pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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