| Lactosucrose inhibits body fat accumulation in rats by decreasing intestinal lipid absorption. | |
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MedLine Citation:
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PMID: 19270366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactosucrose (LS, 4(G)-beta-D-galactosylsucrose) is a non-digestible oligosaccharide, and the consumption of LS selectively increases the proportion of intestinal bifidobacteria. We examined in this study the hypolipidemic potential of LS. An oral triolein tolerance test on rats indicated that LS reduced the elevation of serum triglyceride (TG) and free fatty acids (FFA). Furthermore, LS inhibited the enzymatic digestion of triolein by pancreatic lipase in vitro. NMR spectroscopy showed that LS formed an intermolecular complex with triolein. The long-term consumption of a diet containing 5% LS for 8 weeks significantly decreased the weight of abdominal adipose tissue when compared with that of the control group. Thus, LS may reduce adipose tissue accumulation by inhibiting intestinal lipid absorption via a direct interaction with TG. |
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Authors:
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Akiko Mizote; Yoshifumi Taniguchi; Yasuhiko Takei; Satomi Koya-Miyata; Keizo Kohno; Kanso Iwaki; Mayumi Kurose; Kazuyuki Oku; Hiroto Chaen; Shigeharu Fukuda |
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Publication Detail:
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Type: Journal Article Date: 2009-03-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 73 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 582-7 Citation Subset: IM |
Affiliation:
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Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan. fujisaki@hayashibara.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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drug effects,
metabolism Adipose Tissue / drug effects*, metabolism* Animals Dietary Supplements Fatty Acids, Nonesterified / blood Intestinal Absorption / drug effects* Lipase / metabolism Lipid Metabolism / drug effects* Male Obesity / prevention & control Pancreas / enzymology Rats Rats, Wistar Time Factors Triglycerides / blood Triolein / metabolism Trisaccharides / metabolism, pharmacology* Veins / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Triglycerides; 0/Trisaccharides; 122-32-7/Triolein; 87419-56-5/galactosucrose; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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