Document Detail

Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients.
MedLine Citation:
PMID:  22453291     Owner:  NLM     Status:  MEDLINE    
As decreased bone mineral density (BMD) is a common problem in cystic fibrosis (CF) and milk products may have pivotal dietary role affecting BMD, we aimed to assess the potential influence of adult-type hypolactasia (ATH) and lactose malabsorption (LM) on BMD in adolescent and young adult patients. In 95 CF pancreatic-insufficient patients aged 10-25 years (without liver cirrhosis, steatosis and cholestasis, diabetes mellitus, systemic glucocorticoid therapy), lumbar BMD, the nutritional status, pulmonary function, vitamin D3 concentration, calcium intake and single-nucleotide polymorphism upstream of the lactase gene were assessed. In subjects with the -13910 C/C genotype predisposing to ATH, the presence of LM was determined with the use of a hydrogen-methane breath test (BT). BMD and calcium intake were significantly lower in patients with the C/C genotype (P<0.028 and P<0.043, respectively). The abnormal BMD was stated more frequently in patients with the C/C genotype (P<0.042) and with LM (P<0.007). BMD, daily calcium intake and serum vitamin D concentration were significantly lower in LM subjects than in the other patients (P<0.037, P<0.000004 and P<0.0038, respectively). In logistic regression analysis, the relationship between examined parameters and BMD, was found to be statistically significant (P<0.001). However, only standardized body weight and LM were documented to influence BMD (P<0.025 and P<0.044, respectively). In conclusion, LM seems to be an independent risk factor for decreased BMD in CF patients.
Edyta Mądry; Beata Krasińska; Sławomira Drzymała-Czyż; Dorota Sands; Aleksandra Lisowska; Philip Grebowiec; Alina Minarowska; Beata Oralewska; Przemyslaw Mańkowski; Jerzy Moczko; Jarosław Walkowiak
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-28
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  20     ISSN:  1476-5438     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2013-06-19     Revised Date:  2013-10-13    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  1092-5     Citation Subset:  IM    
Department of Physiology, Poznań University of Medical Sciences, Szpitalna 27/33,Poznań, Poland.
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MeSH Terms
Body Weight
Bone Demineralization, Pathologic / etiology*,  genetics
Bone Density / genetics*
Breath Tests
Calcium / metabolism
Cholecalciferol / blood
Cystic Fibrosis / complications*
Lactase / deficiency,  genetics
Lactose Intolerance / complications,  genetics*
Polymorphism, Single Nucleotide
Promoter Regions, Genetic / genetics
Risk Factors
Reg. No./Substance:
67-97-0/Cholecalciferol; 7440-70-2/Calcium; EC

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