Document Detail

Lactose malabsorption and intolerance: a systematic review on the diagnostic value of gastrointestinal symptoms and self-reported milk intolerance.
MedLine Citation:
PMID:  20522486     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When lactose malabsorption gives rise to symptoms, the result is called 'lactose intolerance'. Although lactose intolerance is often bothersome for patients, once recognized it may be managed by simple dietary adjustments. However, diagnosing lactose intolerance is not straightforward, especially in primary care.
AIM: To summarize available evidence on the diagnostic performance of gastrointestinal symptoms and self-reported milk (lactose) intolerance in primary care, and the relationship between lactose malabsorption and intolerance.
DATA SOURCES: PubMed, EMBASE and reference screening.
STUDY SELECTION: Studies were selected if the design was a primary diagnostic study; the patients were adults consulting because of non-acute abdominal symptoms; the diagnostic test included gastrointestinal symptoms and/or self-reported milk intolerance. A total of 26 primary diagnostic studies were included in the review.
DATA EXTRACTION: Quality assessment and data extraction were performed by two reviewers independently. They adhered to the most recent guidelines for conducting a diagnostic review as described in the Cochrane Diagnostic Reviewers' Handbook.
RESULTS: The diagnostic performance of diarrhea, abdominal pain, bloating, flatulence and self-reported milk intolerance was highly variable. A non-Caucasian ethnic origin was associated with the presence of lactose malabsorption. Both lactose malabsorbers and lactose absorbers reported symptoms during the lactose hydrogen breath test.
CONCLUSION: Our review shows that high-quality studies on the diagnosis of lactose malabsorption and intolerance in primary care are urgently needed. An important prerequisite would be to clearly define the concept of lactose intolerance, as well as how it should be assessed.
P Jellema; F G Schellevis; D A W M van der Windt; C M F Kneepkens; H E van der Horst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-03
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  103     ISSN:  1460-2393     ISO Abbreviation:  QJM     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2011-02-22     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-72     Citation Subset:  IM    
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MeSH Terms
Diagnostic Self Evaluation*
Lactose Intolerance / diagnosis*,  psychology
Predictive Value of Tests
Reference Values
Severity of Illness Index*

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