Document Detail

Lactose malabsorption and intolerance and peak bone mass.
MedLine Citation:
PMID:  12055586     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Lactose malabsorption per se is not associated with alterations of bone mineral density (BMD) or calcium intake, but when intolerance symptoms are present a lower calcium intake and reduction of BMD values are evident. The purpose of this study was to evaluate whether lactose intolerance interferes with the achievement of an adequate peak bone mass in young adults. METHODS: Of 103 enrolled healthy subjects, 55 proved to be lactose malabsorbers with H(2) breath test after lactose administration, and 29 of them experienced intolerance symptoms (diarrhea, abdominal pain, bloating, flatulence). Lumbar and femoral BMD by dual-energy X-ray absorptiometry was measured, and calcium intake and biochemical indices of bone and mineral metabolism were evaluated. RESULTS: Lumbar and femoral BMD, calcium intake, and mineral metabolism did not differ between malabsorbers and absorbers, although among malabsorbers, intolerant subjects showed significant alterations of all these parameters in comparison with tolerant subjects. A strict correlation was evident between BMD values and both severity of symptoms and calcium intake and between calcium intake and severity of symptoms. CONCLUSIONS: Lactose intolerance prevents the achievement of an adequate peak bone mass and may, therefore, predispose to severe osteoporosis.
Michele Di Stefano; Graziamaria Veneto; Simona Malservisi; Loredana Cecchetti; Licia Minguzzi; Alessandra Strocchi; Gino Roberto Corazza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  122     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1793-9     Citation Subset:  AIM; IM    
Gastroenterology Unit, IRCCS S.Matteo Hospital, University of Pavia, Pavia, Italy.
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MeSH Terms
Absorptiometry, Photon
Bone Density*
Calcium / administration & dosage,  pharmacology
Femur / metabolism
Lactose Intolerance / metabolism*
Lumbar Vertebrae / metabolism
Middle Aged
Reference Values
Severity of Illness Index
Reg. No./Substance:

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