Document Detail

Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case-control study.
MedLine Citation:
PMID:  15370685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Symptoms after intake of milk are common in persons with irritable bowel syndrome (IBS). The aims of this study were to compare the prevalence of lactose malabsorption (LM) and symptoms related to intake of milk and lactose in subjects with IBS with that of healthy volunteers, and to search for symptoms that are characteristic of LM. METHODS: A case-control study in a Norwegian population was initiated. Subjects with IBS were asked for symptoms related to intake of milk and lactose, tested for LM, and compared with a group of healthy volunteers. RESULTS: The study comprised a total of 187 persons (82 with IBS and 105 volunteers), females/males: 138/49, mean age 47 years. In subjects with IBS and in healthy volunteers, LM was present in 3/74 (4.1%) and 4/105 (3.8%), respectively (ns), milk-related symptoms in 32/79 (40%) and 13/105 (12%), respectively (P < 0.001) and symptoms after intake of lactose in 28/74 (38%) and 21/104 (20%), respectively (P=0.01). Borborygmi starting within 5 h after intake of lactose and lasting for more than 2 h indicated LM (OR 61 (95% CI: 8-475), P < 0.001). CONCLUSIONS: IBS and LM are unrelated disorders in a Norwegian population. Milk-related symptoms and symptoms after intake of lactose are unreliable predictors for LM. Precise symptom-based criteria might enhance the diagnostic accuracy for LM.
P G Farup; K W Monsbakken; P O Vandvik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  39     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  645-9     Citation Subset:  IM    
Department of Medicine, Innlandet Hospital Health Authority, Gjøvik, Norway.
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MeSH Terms
Case-Control Studies
Dairy Products / adverse effects
Irritable Bowel Syndrome / complications*
Lactose / adverse effects
Lactose Intolerance / diagnosis,  epidemiology,  etiology*
Lactose Tolerance Test
Middle Aged
Norway / epidemiology
Reg. No./Substance:
Comment In:
Scand J Gastroenterol. 2004 Oct;39(10):1033; author reply 1033   [PMID:  15513350 ]

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