Document Detail

Lactose intolerance: problems in diagnosis and treatment.
MedLine Citation:
PMID:  10192605     Owner:  NLM     Status:  MEDLINE    
Lactose malabsorption and lactase deficiency are chronic organic pathologic conditions characterized by abdominal pain and distention, flatulence, and the passage of loose, watery stools. Though malabsorption of the sugar lactose is determinable by breath hydrogen test or jejunal biopsy, intolerance can only be confirmed by challenge with lactose-containing food, the response to which may not be immediate. The difficulty of making a positive diagnosis of these conditions has led to a proportion of lactose-intolerant patients being misdiagnosed with irritable bowel syndrome (IBS), which has a remarkably similar symptom complex and for which there is no current pathophysiologic marker. The incidence of the two disorders is approximately equal, but the actual proportion of patients with IBS incorrectly diagnosed in this way varies as a function of the methodology used. Once correct diagnosis is established, introduction of a lactose-free dietary regime relieves symptoms in most patients. Symptom similarity and the resultant incorrect diagnosis of IBS may explain the refractory nature of some patients labeled as IBS who remain largely unaware of the relationship between food intake and symptoms.
A D Shaw; G J Davies
Related Documents :
9627625 - Allaying fears and fallacies about lactose intolerance.
14689315 - Evaluation of kluyveromyces marxianus fii 510700 grown on a lactose-based medium as a s...
25446205 - The impact of individual variations in taste sensitivity on coffee perceptions and pref...
2691265 - Staphylococcal food poisoning from sheep milk cheese.
3570115 - Computer automated structure evaluation of the carcinogenicity of n-nitrosothiazolidine...
18855155 - Product stewardship in wollastonite production.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  28     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-24     Completed Date:  1999-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-16     Citation Subset:  IM    
Nutrition Research Centre, School of Applied Science, South Bank University, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breath Tests
Colonic Diseases, Functional / diagnosis
Diagnosis, Differential
Lactose Intolerance / diagnosis*,  epidemiology,  therapy*
Lactose Tolerance Test

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of achalasia: recent advances in surgery.
Next Document:  Standardization in endoscopic reporting: implications for clinical practice and research.