| Lactogenic and somatotropic binding sites in liver membranes of rats with renal insufficiency. | |
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MedLine Citation:
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PMID: 6245858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Binding sites for human GH (hGH) were studied in liver membranes of rats with chronic renal insufficiency (CRI) associated with marked growth retardation. A subtotal nephrectomy was performed in young female rats. One month after the nephrectomy, the animals with a plasma creatinine level 3 times or more that of controls were studied; their mean statural gain was 56% that of controls. The specific binding of [125I]hGH to microsomal membranes of rats with CRI was low (40% that of controls). The number of binding sites rather than the affinity of the binding was affected; both the lactogenic and somatotropic sites were decreased, as judged from the binding of ovine [125I]PRL and bovine [125I]GH. The binding sites of the plasma membranes as well as those of the Golgi fractions, were reduced. In plasma membranes of rats with CRI, the specific binding of glucagon was low, and the specific binding of insulin was elevated; these modifications were associated with a high plasma glucagon level and a decreased insulinemia in rats with CRI, but no modification of plasma GH and PRL levels was found. Thus, the hormone level does not appear to regulate the GH-binding sites in this system. The link between the growth defect and the decreased number of GH-binding sites in the liver membranes of rats with CRI remains to be established. |
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Authors:
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J Finidori; M C Postel-Vinay; C Kleinknecht |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinology Volume: 106 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-07-26 Completed Date: 1980-07-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1960-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / metabolism Creatinine / blood Disease Models, Animal Female Glucagon / blood Growth Hormone / metabolism* Insulin / blood Kidney Failure, Chronic / metabolism* Liver / metabolism* Nucleotidases / metabolism Prolactin / metabolism* Rats Receptors, Cell Surface / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 11061-68-0/Insulin; 60-27-5/Creatinine; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone; 9007-92-5/Glucagon; EC 3.1.3.-/Nucleotidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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