Document Detail

Lactogenic hormone signal transduction.
MedLine Citation:
PMID:  9475379     Owner:  NLM     Status:  MEDLINE    
The peptide hormone prolactin (PRL) is known to regulate numerous target tissues. Among the less well-known targets are cells of the immune system, including T cells, B cells, and macrophages. Our laboratory has cloned a panel of PRL-inducible T-cell activation genes for use in studies investigating how PRL modulates the biology of cells of the immune system. This article focuses on two such PRL-inducible genes. One is a transcription factor called interferon regulatory factor-1, whose expression is regulated by signaling molecules along the PRL-inducible JAK/Stat signaling pathway. These signaling molecules include Stat1 and CBP as positive mediators and, unexpectedly, Stat5b as a negative mediator. A second PRL-inducible gene is c15/RNUDC, a novel nuclear movement protein, which may provide a link between PRL signaling and signaling via the lipid second messenger, platelet activating factor.
L Y Yu-Lee; G Luo; M L Book; S M Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Biology of reproduction     Volume:  58     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-30     Completed Date:  1998-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  295-301     Citation Subset:  IM    
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Prolactin / physiology*
Signal Transduction / physiology*
Grant Support
Reg. No./Substance:

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