| Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. | |
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MedLine Citation:
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PMID: 20407805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women. |
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Authors:
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Rosalba Paesano; Francesca Berlutti; Miriam Pietropaoli; Fabrizio Pantanella; Enrica Pacifici; William Goolsbee; Piera Valenti |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-21 |
Journal Detail:
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Title: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine Volume: 23 ISSN: 1572-8773 ISO Abbreviation: Biometals Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208478 Medline TA: Biometals Country: Netherlands |
Other Details:
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Languages: eng Pagination: 411-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrician and Gynaecology, Sapienza University of Rome, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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drug therapy* Animals Female Ferrous Compounds / administration & dosage, adverse effects, therapeutic use* Humans Iron / deficiency* Lactoferrin / administration & dosage, immunology, therapeutic use* Pregnancy Pregnancy Complications, Hematologic / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Ferrous Compounds; 0/Lactoferrin; 7439-89-6/Iron; 7720-78-7/ferrous sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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