Document Detail


Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women.
MedLine Citation:
PMID:  20407805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women.
Authors:
Rosalba Paesano; Francesca Berlutti; Miriam Pietropaoli; Fabrizio Pantanella; Enrica Pacifici; William Goolsbee; Piera Valenti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-21
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  23     ISSN:  1572-8773     ISO Abbreviation:  Biometals     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrician and Gynaecology, Sapienza University of Rome, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / drug therapy*
Animals
Female
Ferrous Compounds / administration & dosage,  adverse effects,  therapeutic use*
Humans
Iron / deficiency*
Lactoferrin / administration & dosage,  immunology,  therapeutic use*
Pregnancy
Pregnancy Complications, Hematologic / drug therapy*
Chemical
Reg. No./Substance:
0/Ferrous Compounds; 0/Lactoferrin; 7439-89-6/Iron; 7720-78-7/ferrous sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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