Document Detail

Lactococcus lactis ssp. lactis inhibits the proliferation of SNU-1 human stomach cancer cells through induction of G0/G1 cell cycle arrest and apoptosis via p53 and p21 expression.
MedLine Citation:
PMID:  19723065     Owner:  NLM     Status:  MEDLINE    
We investigated the antiproliferative effects of the cytoplasmic fraction of Lactococcus lactis ssp. lactis (L.lac CF) on the SNU-1 human stomach cancer cell line. The proliferation of SNU-1 cells was inhibited by treatment with L.lac CF in a time- and dose-dependent manner. L.lac CF caused G0/G1 cell cycle arrest, which was associated with an increase in p53 and p21 expression, the reduction of cyclin D1 expression, and retinoblastoma protein phosphorylation. L.lac CF induced apoptosis in SNU-1 cells, as demonstrated by increased nucleus condensation and a sub-G1 peak. Caspase-3 activation, the induction of p53, and the downregulation of Bcl-2 were also observed in L.lac CF-treated cells. Thus, the inhibitory effect of L.lac CF on SNU-1 cell growth is mainly attributable to the induction of G0/G1 cell cycle arrest and apoptosis.
Seo Young Kim; Jong-Eun Kim; Ki Won Lee; Hyong Joo Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1171     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  IM    
Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
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MeSH Terms
Apoptosis / drug effects*
Biological Factors / chemistry,  pharmacology*
Blotting, Western
Caspase 3 / metabolism
Cell Cycle / drug effects*
Cell Line, Tumor
Cell Proliferation / drug effects*
Cell Survival / drug effects
Cyclin D1 / metabolism
Cyclin-Dependent Kinase Inhibitor p21 / metabolism*
Dose-Response Relationship, Drug
Flow Cytometry
G0 Phase / drug effects
G1 Phase / drug effects
Lactococcus lactis / chemistry*
Phosphorylation / drug effects
Retinoblastoma Protein / metabolism
Stomach Neoplasms / metabolism,  pathology
Time Factors
Tumor Suppressor Protein p53 / metabolism*
Reg. No./Substance:
0/Biological Factors; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Retinoblastoma Protein; 0/Tumor Suppressor Protein p53; 136601-57-5/Cyclin D1; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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