| Lactobionic acid as an iron chelator: a rationale for its effectiveness as an organ preservant. | |
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MedLine Citation:
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PMID: 2601586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactobionic acid, a major constituent of a solution used to preserve organs prior to transplantation, can chelate ferric iron. This is evident by its ability to solubilize iron as well as changes that occur in the UV-VIS spectra of iron in its presence. Relative to iron (III) chelated to EDTA, the lactobionic acid-iron (III) complex is less able to participate in the Fenton reaction as measured by formaldehyde generation from DMSO and bleaching of p-N,N-dimethylnitrosoaniline. Similar effects are seen with citrate and ATP, two substances which also appear to be able to ameliorate ischemia/reperfusion injury. These findings present a rationale for the effectiveness of lactobionic acid as an organ preservant. |
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Authors:
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Y Isaacson; O Salem; R E Shepherd; D H Van Thiel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 45 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-02-08 Completed Date: 1990-02-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2373-80 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pittsburgh, PA 15261. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Dimethyl Sulfoxide / metabolism Disaccharides / pharmacology* Formaldehyde / metabolism Free Radicals Iron Chelating Agents* Molecular Conformation Organ Preservation* Reperfusion Injury / prevention & control Spectrophotometry, Ultraviolet |
| Grant Support | |
ID/Acronym/Agency:
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DK32556/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Disaccharides; 0/Free Radicals; 0/Iron Chelating Agents; 50-00-0/Formaldehyde; 67-68-5/Dimethyl Sulfoxide; 96-82-2/lactobionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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