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Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants.
MedLine Citation:
PMID:  21114493     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Eur J Clin Invest 2011; 41 (4): 417-422 ABSTRACT: Background  Young infants are frequently affected by uncomplicated regurgitation that may persist despite dietetic and conservative interventions. On this basis, we studied the putative effects of probiotics on the frequency of regurgitation and gastric emptying time in infants with functional gastroesophageal reflux (GER). Patients and methods  Forty-two infants with regurgitation were randomized to assume Lactobacillus reuteri DSM 17938 at a dose of 1 × 10(8)  CFU per day and placebo for 30 days. The episodes of regurgitation were recorded by the parents each day. Gastric emptying time was recorded using real-time ultrasound at baseline and at the end of the study. Twenty-one infants without regurgitation were enroled to compare anthropometric and physiological parameters before the intervention diet. Results  Thirty-four infants completed the study (19 infants receiving probiotics and 15 placebo).At baseline, the whole group of infants was similar to the control group as regards anthropometric and physiological data. The median fasting antral area was significantly reduced, (P = 0·01) the delta in gastric emptying rate was significantly increased (P = 0·01) and the median episodes per day of regurgitation was reduced (, P < 0·001) in the probiotic group compared to the placebo group. In the whole group, the frequency of regurgitation and the basal antral area showed a positive correlation (r = 0·53, P = 0·004). Conclusions  In infants with functional GER, L. reuteri DSM 17938 reduce gastric distension and accelerate gastric emptying. In addition, this probiotic strain seems to diminish the frequency of regurgitation.
Authors:
Flavia Indrio; Giuseppe Riezzo; Francesco Raimondi; Massimo Bisceglia; Antonia Filannino; Luciano Cavallo; Ruggiero Francavilla
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Publication Detail:
Type:  Journal Article     Date:  2010-11-26
Journal Detail:
Title:  European journal of clinical investigation     Volume:  41     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  417-22     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. European Journal of Clinical Investigation © 2010 Stichting European Society for Clinical Investigation Journal Foundation.
Affiliation:
Department of Pediatrics, University of Bari Policlinico Piazza G.Cesare, Bari Laboratory of Experimental Pathophysiology, National Institute for Digestive Diseases I.R.C.C.S. 'Saverio de Bellis', Castellana Grotte, Bari Department of Pediatrics, University Federico II Policlinico, Naples Department of Pediatrics, Ospedale San Giovanni di Dio, Crotone, Italy.
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