Document Detail

Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study.
MedLine Citation:
PMID:  17200238     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The goal was to test the hypothesis that oral administration of Lactobacillus reuteri in a prospective randomized study would improve symptoms of infantile colic. METHODS: Ninety breastfed colicky infants were assigned randomly to receive either the probiotic L. reuteri (10(8) live bacteria per day) or simethicone (60 mg/day) each day for 28 days. The mothers avoided cow's milk in their diet. Parents monitored daily crying times and adverse effects by using a questionnaire. RESULTS: Eighty-three infants completed the trial: 41 in the probiotic group and 42 in the simethicone group. The infants were similar regarding gestational age, birth weight, gender, and crying time at baseline. Daily median crying times in the probiotic and simethicone groups were 159 minutes/day and 177 minutes/day, respectively, on the seventh day and 51 minutes/day and 145 minutes/day on the 28th day. On day 28, 39 patients (95%) were responders in the probiotic group and 3 patients (7%) were responders in the simethicone group. No adverse effects were reported. CONCLUSIONS: In our cohort, L. reuteri improved colicky symptoms in breastfed infants within 1 week of treatment, compared with simethicone, which suggests that probiotics may have a role in the treatment of infantile colic.
Francesco Savino; Emanuela Pelle; Elisabetta Palumeri; Roberto Oggero; Roberto Miniero
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics     Volume:  119     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-03     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e124-30     Citation Subset:  AIM; IM    
Department of Pediatrics, Regina Margherita Children's Hospital, University of Turin, Piazza Polonia, 94 10126 Turin, Italy.
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MeSH Terms
Antifoaming Agents / therapeutic use*
Breast Feeding
Colic / therapy*
Infant, Newborn
Lactobacillus reuteri*
Probiotics / therapeutic use*
Simethicone / therapeutic use*
Reg. No./Substance:
0/Antifoaming Agents; 8050-81-5/Simethicone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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