Document Detail

Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta.
MedLine Citation:
PMID:  14617125     Owner:  NLM     Status:  MEDLINE    
We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture. He developed lacticacidosis after short-term propofol infusion (150 min, mean infusion rate 13.5 associated with a prolonged recovery time without serious haemodynamic changes. The highest lactate concentration was 9.2 mmol.l-1 at 160 min after discontinuation of propofol. There was no significant increase in body temperature. The boy fully recovered.
Clemens Kill; Andreas Leonhardt; Hinnerk Wulf
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  13     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  823-6     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care Medicine, Philipps-University, Marburg, Germany.
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MeSH Terms
Acidosis, Lactic / blood,  chemically induced*
Anesthesia, Intravenous / adverse effects*
Anesthetics, Intravenous / adverse effects*
Dose-Response Relationship, Drug
Fasting / metabolism
Femoral Fractures / complications,  surgery
Fentanyl / administration & dosage
Hemodynamics / drug effects
Lactic Acid / blood
Neuromuscular Nondepolarizing Agents / administration & dosage
Osteogenesis Imperfecta / complications*
Propofol / adverse effects*
Succinylcholine / administration & dosage
Time Factors
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Neuromuscular Nondepolarizing Agents; 2078-54-8/Propofol; 306-40-1/Succinylcholine; 437-38-7/Fentanyl; 50-21-5/Lactic Acid

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