Document Detail

Lactic response in sickle cell trait carriers in comparison with subjects with normal hemoglobin.
MedLine Citation:
PMID:  12629427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to assess lactic response (mmol/L) during incremental exercise in a specific population of men and women with sickle cell trait. SUBJECTS: Athletic men and women from the French West Indies showing no anemia and/or alpha thalassemia. METHODS: Anemia was ruled out by hemoglobin level, and alpha thalassemia was ruled out by hemoglobin S percentage with concomitant hemoglobin level and mean corpuscular volume. Comparison was made with control subjects with normal hemoglobin, matched for physical fitness, anthropometric data, and sex. All subjects performed an incremental exercise test using a cycle ergometer. Peak oxygen uptake (mL/min) was predicted from an equation at peak exercise. Heart rate (beats/min) was noted continuously, and blood samples were collected for lactic response determination every minute during the incremental exercise test and at 1, 3, and 5 minutes of recovery. RESULTS: Comparison of peak oxygen uptake and heart rate values showed no significant differences in subjects with sickle cell trait versus control subjects during the incremental exercise test. In contrast, analysis of variance revealed significantly lower lactic response time courses during the incremental exercise test and at peak exercise (p < 0.05) in the sickle cell trait group, whereas the heart rate time course was lower during recovery (p < 0.05). CONCLUSION: We conclude that the lower lactic response exhibited by subjects with sickle cell trait during incremental exercise was the result of an adaptive process in red blood cells in relation to either lower lactate production or greater lactate uptake capability than in individuals with normal hemoglobin.
Fagnété Sara; Marie-Dominique Hardy-Dessources; Bruno Voltaire; Maryse Etienne-Julan; Olivier Hue
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  13     ISSN:  1050-642X     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Université des Antilles et de la Guyane, Pinte á Pitre, Guadeloupe.
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MeSH Terms
Adaptation, Physiological
Erythrocytes / physiology
Exercise / physiology*
Exercise Test
Heart Rate
Lactic Acid / blood*
Oxygen Consumption
Physical Fitness / physiology
Sickle Cell Trait / blood*
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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