| Lactic acidosis in the rectal lumen of patients with septic shock measured by luminal equilibrium dialysis. | |
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MedLine Citation:
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PMID: 12453938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gut ischaemia may contribute to morbidity in sepsis, but little is known about the metabolic state of the gut mucosa in such patients. METHODS: Nine patients with abdominal septic shock treated with norepinephrine, and ten healthy subjects, were subjected to equilibrium dialysis with a rectal balloon. pH, PCO(2) and concentrations of L-lactate were measured by auto-analyser. RESULTS: In rectal dialysis fluid from patients with septic shock, acidosis was present (pH 7.23, 95% CI 7.11-7.36) and concentrations of L-lactate were approximately five times greater than controls (2.5-5.8 vs 0.5-1.2 mmol litre(-1)). The lactate concentration was related to the dose of norepinephrine (P<0.001). In contrast, values of dialysate PCO(2) did not differ significantly between patients and controls (6.4-11.0 vs 8.9-13.8 kPa). CONCLUSIONS: The results suggest that, either lactic acidosis in rectal mucosa is related to shock severity, or that norepinephrine causes mucosal ischaemia. In any case, metabolic dysfunction is present in the rectal mucosa in patients with abdominal septic shock treated with norepinephrine. |
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Authors:
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V Due; J Bonde; K Espersen; T H Jensen; A Perner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 89 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-01-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 919-22 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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metabolism* Adult Aged Case-Control Studies Dialysis / methods Humans Intestinal Mucosa / metabolism Middle Aged Rectum / metabolism* Shock, Septic / metabolism* |
| Comments/Corrections | |
Erratum In:
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Br J Anaesth. 2003 Mar;90(3):424. |
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