Document Detail

Lactic acid and amino acid fluctuations measured using microdialysis reflect physiological derangements in head injury.
MedLine Citation:
PMID:  8870799     Owner:  NLM     Status:  MEDLINE    
We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.
J C Goodman; S P Gopinath; A B Valadka; R K Narayan; R G Grossman; R K Simpson; C S Robertson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  67     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  37-9     Citation Subset:  IM    
Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Amino Acids / metabolism*
Brain / metabolism
Brain Death / metabolism
Craniocerebral Trauma / metabolism*,  physiopathology*
Extracellular Space / metabolism
Intracranial Pressure
Jugular Veins
Lactic Acid / metabolism*
Oxygen / blood
Grant Support
Reg. No./Substance:
0/Amino Acids; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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