| Lactation and maternal risk of type 2 diabetes: a population-based study. | |
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MedLine Citation:
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PMID: 20800156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lactation has been associated with improvements in maternal glucose metabolism. METHODS: We explored the relationships between lactation and risk of type 2 diabetes in a well-characterized, population-representative cohort of women, aged 40-78 years, who were members of a large integrated health care delivery organization in California and enrolled in the Reproductive Risk factors for Incontinence Study at Kaiser (RRISK), between 2003 and 2008. Multivariable logistic regression was used to control for age, parity, race, education, hysterectomy, physical activity, tobacco and alcohol use, family history of diabetes, and body mass index while examining the impact of duration, exclusivity, and consistency of lactation on risk of having developed type 2 diabetes. RESULTS: Of 2233 women studied, 1828 were mothers; 56% had breastfed an infant for > or =1 month. In fully adjusted models, the risk of type 2 diabetes among women who consistently breastfed all of their children for > or =1 month remained similar to that of women who had never given birth (odds ratio [OR] 1.01; 95% confidence interval [CI], 0.56-1.81). In contrast, mothers who had never breastfed an infant were more likely to have developed type 2 diabetes than nulliparous women (OR 1.93; 95% CI, 1.14-3.27) [corrected]. Mothers who never exclusively breastfed were more likely to have developed type 2 diabetes than mothers who exclusively breastfed for 1-3 months (OR 1.52; 95% CI, 1.11-2.10). CONCLUSIONS: Risk of type 2 diabetes increases when term pregnancy is followed by <1 month of lactation, independent of physical activity and body mass index in later life. Mothers should be encouraged to exclusively breastfeed all of their infants for at least 1 month. |
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Authors:
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Eleanor Bimla Schwarz; Jeanette S Brown; Jennifer M Creasman; Alison Stuebe; Candace K McClure; Stephen K Van Den Eeden; David Thom |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of medicine Volume: 123 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-13 Revised Date: 2011-11-23 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 863.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Pittsburgh, PA, USA. schwarzeb@upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Glucose / metabolism* Body Mass Index Breast Feeding California / epidemiology Diabetes Mellitus, Type 2 / epidemiology, metabolism, prevention & control* Female Humans Lactation / metabolism* Logistic Models Middle Aged Multivariate Analysis Odds Ratio Pregnancy Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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K23 HD051585-01/HD/NICHD NIH HHS; K23 HD051585-04/HD/NICHD NIH HHS; K24 DK059294-09/DK/NIDDK NIH HHS; P50 DK064538/DK/NIDDK NIH HHS; P50 DK064538-010001/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
Erratum In:
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Am J Med. 2011 Oct;124(10):e9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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