Document Detail

Lactate turnover at rest and during submaximal exercise in patients with heart failure.
MedLine Citation:
PMID:  8307848     Owner:  NLM     Status:  MEDLINE    
Systemic and lower limb skeletal muscle lactate metabolism was studied in 10 men with congestive heart failure by use of a primed continuous intravenous infusion of L-(+)-[U-14C]lactate. Arterial and deep femoral venous blood samples were obtained at rest and during 30 min of submaximal exercise. Systemic lactate metabolic turnover rate (Rd) was determined using Steele's isotopic steady-state equation (Rd = isotopic infusion rate/arterial specific activity). Plasma lactate concentrations in the artery and deep femoral vein did not change significantly from resting values during exercise (1.11 +/- 0.13 vs. 1.26 +/- 0.12 and 1.27 +/- 0.12 vs. 1.30 +/- 0.12 mM, respectively), whereas Rd increased from 22.5 +/- 1.8 to 41.6 +/- 4.8 (P < 0.005). Rd did not significantly correlate with arterial lactate concentration during rest or exercise. Because of simultaneous uptake and release of lactate in skeletal muscle, arterial and deep femoral venous lactate concentrations are not closely related to either systemic or lower limb skeletal muscle lactate metabolism in patients with congestive heart failure.
S D Katz; B Bleiberg; J Wexler; K Bhargava; J J Steinberg; T H LeJemtel
Related Documents :
10211858 - Comparison between the physiological response to roller skiing and in-line skating in b...
1406198 - Substrate utilization during treadmill running in prepubertal girls and women.
21266928 - Association of military training with oxidative stress and overreaching.
24207068 - Aerobic training in adults after atrial switch procedure for transposition of the great...
10226888 - Immunological response in chronic fatigue syndrome following a graded exercise test to ...
9189728 - Effect of ubiquinone on exercise-induced lipid peroxidation in rat tissues.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1974-9     Citation Subset:  IM; S    
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Chronic Disease
Exercise / physiology*
Heart Failure / metabolism*
Lactates / metabolism*
Middle Aged
Muscles / metabolism*
Rest / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Autonomic regulation of heart rate response to exercise in Tibetan and Han residents of Lhasa (3,658...
Next Document:  Effect of humidity on hyperoxic toxicity.