Document Detail

Lactate turnover at rest and during submaximal exercise in patients with heart failure.
MedLine Citation:
PMID:  8307848     Owner:  NLM     Status:  MEDLINE    
Systemic and lower limb skeletal muscle lactate metabolism was studied in 10 men with congestive heart failure by use of a primed continuous intravenous infusion of L-(+)-[U-14C]lactate. Arterial and deep femoral venous blood samples were obtained at rest and during 30 min of submaximal exercise. Systemic lactate metabolic turnover rate (Rd) was determined using Steele's isotopic steady-state equation (Rd = isotopic infusion rate/arterial specific activity). Plasma lactate concentrations in the artery and deep femoral vein did not change significantly from resting values during exercise (1.11 +/- 0.13 vs. 1.26 +/- 0.12 and 1.27 +/- 0.12 vs. 1.30 +/- 0.12 mM, respectively), whereas Rd increased from 22.5 +/- 1.8 to 41.6 +/- 4.8 (P < 0.005). Rd did not significantly correlate with arterial lactate concentration during rest or exercise. Because of simultaneous uptake and release of lactate in skeletal muscle, arterial and deep femoral venous lactate concentrations are not closely related to either systemic or lower limb skeletal muscle lactate metabolism in patients with congestive heart failure.
S D Katz; B Bleiberg; J Wexler; K Bhargava; J J Steinberg; T H LeJemtel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1974-9     Citation Subset:  IM; S    
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
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MeSH Terms
Aged, 80 and over
Chronic Disease
Exercise / physiology*
Heart Failure / metabolism*
Lactates / metabolism*
Middle Aged
Muscles / metabolism*
Rest / physiology*
Reg. No./Substance:

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