Document Detail


Lactate-transport activity in RBCs of trained and untrained individuals from four racing species.
MedLine Citation:
PMID:  11404274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In red blood cells (RBC) of horses, both lactate-transport activity and lactate accumulation during races vary interindividually. To study whether similar variation in lactate transport is apparent also in RBCs of other racing species, blood samples were collected from 21 reindeer, 40 horses, 31 humans, and 38 dogs. Total lactate-transport activity was measured at 10 and 30 mM concentrations, and the roles of the monocarboxylate-transporter (MCT) and the inorganic anion-exchange transporter (band-3 protein) were studied with inhibitors. In the reindeer and in one-third of the horses, lactate transport was low and mediated mainly by band-3 protein and nonionic diffusion. In the humans, dogs, and the remaining two-thirds of the horses, lactate transport was high and MCT was the main transporter. No correlation existed between MCT activity and the athleticism of the species. In the horses and humans, training had no effect on lactate transport, but in the reindeer and sled dogs, training increased total lactate transport. These results show that among the racing species studied, only in horses was the distribution of lactate-transport activity bimodal, and the possible connection between RBC lactate and performance capacity, especially in this species, warrants further studies.
Authors:
L K Väihkönen; O J Heinonen; S Hyyppä; M Nieminen; A R Pösö
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  281     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R19-24     Citation Subset:  IM    
Affiliation:
Department of Basic Veterinary Sciences, University of Helsinki, FIN-00014 Helsinki, Finland. leena.vaihkonen@pp.phnet.fi
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MeSH Terms
Descriptor/Qualifier:
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / pharmacology
Adolescent
Adult
Animals
Anion Exchange Protein 1, Erythrocyte / metabolism
Biological Transport / drug effects,  physiology
Carrier Proteins / metabolism
Coumaric Acids / pharmacology
Deer
Dogs
Erythrocytes / metabolism*
Female
Horses
Humans
Lactic Acid / blood*
Male
Middle Aged
Monocarboxylic Acid Transporters
Physical Exertion / physiology*
Running / physiology*
Species Specificity
Chemical
Reg. No./Substance:
0/Anion Exchange Protein 1, Erythrocyte; 0/Carrier Proteins; 0/Coumaric Acids; 0/Monocarboxylic Acid Transporters; 28166-41-8/alpha-cyano-4-hydroxycinnamate; 50-21-5/Lactic Acid; 53005-05-3/4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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