| Lactate-transport activity in RBCs of trained and untrained individuals from four racing species. | |
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MedLine Citation:
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PMID: 11404274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In red blood cells (RBC) of horses, both lactate-transport activity and lactate accumulation during races vary interindividually. To study whether similar variation in lactate transport is apparent also in RBCs of other racing species, blood samples were collected from 21 reindeer, 40 horses, 31 humans, and 38 dogs. Total lactate-transport activity was measured at 10 and 30 mM concentrations, and the roles of the monocarboxylate-transporter (MCT) and the inorganic anion-exchange transporter (band-3 protein) were studied with inhibitors. In the reindeer and in one-third of the horses, lactate transport was low and mediated mainly by band-3 protein and nonionic diffusion. In the humans, dogs, and the remaining two-thirds of the horses, lactate transport was high and MCT was the main transporter. No correlation existed between MCT activity and the athleticism of the species. In the horses and humans, training had no effect on lactate transport, but in the reindeer and sled dogs, training increased total lactate transport. These results show that among the racing species studied, only in horses was the distribution of lactate-transport activity bimodal, and the possible connection between RBC lactate and performance capacity, especially in this species, warrants further studies. |
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Authors:
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L K Väihkönen; O J Heinonen; S Hyyppä; M Nieminen; A R Pösö |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 281 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-07-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R19-24 Citation Subset: IM |
Affiliation:
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Department of Basic Veterinary Sciences, University of Helsinki, FIN-00014 Helsinki, Finland. leena.vaihkonen@pp.phnet.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
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pharmacology Adolescent Adult Animals Anion Exchange Protein 1, Erythrocyte / metabolism Biological Transport / drug effects, physiology Carrier Proteins / metabolism Coumaric Acids / pharmacology Deer Dogs Erythrocytes / metabolism* Female Horses Humans Lactic Acid / blood* Male Middle Aged Monocarboxylic Acid Transporters Physical Exertion / physiology* Running / physiology* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Anion Exchange Protein 1, Erythrocyte; 0/Carrier Proteins; 0/Coumaric Acids; 0/Monocarboxylic Acid Transporters; 28166-41-8/alpha-cyano-4-hydroxycinnamate; 50-21-5/Lactic Acid; 53005-05-3/4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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