Document Detail


Lactate transfer across the perfused human placenta.
MedLine Citation:
PMID:  3737576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transfer of lactate across the human placenta was investigated using an in vitro dually-perfused placental preparation. Using a novel technique, the unidirectional flux of L-lactate was found to be linearly dependent on L-lactate concentration. In addition, unidirectional transfer rates were found to be the same in both maternal-to-fetal and fetal-to-maternal directions at the same lactate concentration. Transfer of [14C]L-lactate was decreased by approximately 15 per cent in competition with unlabelled L-lactate. Stereospecificity and permeability experiments demonstrated the existence of a transfer mechanism which could distinguish between the L- and D-isomers of lactate. Our data suggest that, while a stereospecific carrier for lactate exists in the perfused placenta, the bulk of transplacental lactate transfer takes place by non-carrier-mediated diffusion.
Authors:
N P Illsley; R Wootton; P Penfold; S Hall; S Duffy
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Placenta     Volume:  7     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antipyrine / metabolism
Carbon Radioisotopes / diagnostic use
Female
Humans
Lactates / blood,  metabolism*
Lactic Acid
Maternal-Fetal Exchange*
Molecular Weight
Perfusion
Pregnancy
Stereoisomerism
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Lactates; 50-21-5/Lactic Acid; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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