| Lactate threshold is not an onset of insufficient oxygen supply to the working muscle in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 8088025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been argued that the lactate threshold (LT) serves as an index to reflect circulatory insufficiency in transporting oxygen during submaximal exercise in patients with chronic heart failure (CHF). We examined whether or not the LT was related to an insufficient oxygen supply in patients with CHF. Sixty-nine patients were divided by NYHA classification. All underwent invasive cardiopulmonary exercise testing. The rate of increase in oxygen delivery (O2D) versus VO2 (delta O2D/delta VO2) was significantly lowered when work rate exceeded LT, that is, 1.32 +/- 0.35 to 1.05 +/- 0.37 (p < 0.01), 1.22 +/- 0.40 to 0.98 +/- 0.40 (p < 0.05), and 1.04 +/- 0.26 to 0.78 +/- 0.39 (p < 0.05) in NYHA classes I, II, and III, respectively. However, the rate of increase in leg O2D versus leg VO2 (delta LO2D/delta LVO2) did not change, that is, 1.25 +/- 0.20 to 1.29 +/- 0.20 (NS), 1.27 +/- 0.23 to 1.21 +/- 0.28 (NS), and 1.19 +/- 0.24 to 1.15 +/- 0.17 (NS) in classes I, II, and III, respectively. Leg venous PO2 was significantly different among three groups, that is, 23.7 +/- 3.4 mmHg, 23.2 +/- 2.8 mmHg, and 20.1 +/- 2.3 mmHg (p < 0.001), respectively. Thus, the oxygen supply to the working muscle did not become insufficient when work rate exceeded LT, and the LT occurred at different levels of leg PO2. It was concluded that the LT was not a result of anaerobiosis in patients with CHF. |
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Authors:
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H Yamabe; K Itoh; Y Yasaka; T Takata; M Yokoyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 17 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-10-14 Completed Date: 1994-10-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 391-4 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Kobe University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobic Threshold
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physiology* Cardiac Output / physiology Cardiac Output, Low / metabolism*, physiopathology Chronic Disease Exercise Test Female Humans Lactates / metabolism* Leg / blood supply Male Middle Aged Muscles / metabolism*, physiology Oxygen / blood Oxygen Consumption / physiology* Regional Blood Flow / physiology Stroke Volume / physiology |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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