Document Detail

Lactate stress testing in 155 patients with mitochondriopathy.
MedLine Citation:
PMID:  11858534     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Few data are available about the diagnostic yield of the lactate stress test (LST) in a large group of patients with mitochondriopathy (MCP). METHODS: Serum lactate was determined once before, three times during, and once after a 15-minute, constant 30W workload on a bicycle in 62 controls, aged 17 to 84 years, 155 patients with MCP, aged 17 to 87 years, and 31 patients with neurological disorders other than MCP. RESULTS: Lactate's upper reference limits at rest, 5, 10, 15 minutes after starting, and 15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol/l respectively. The test was regarded abnormal if more than two of the five lactate values exceeded the cut-off levels. Among the 103 patients with abnormal LST, 64 (62 %) had normal resting lactate. The sensitivity of the test was 67% and the specificity 94%. CONCLUSION: The LST proved to have a high sensitivity and specificity in the detection of patients with MCP, being thus a simple but powerful tool to assess the impaired oxidative metabolism in MCP patients.
Josef Finsterer; Erika Milvay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  29     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-22     Completed Date:  2002-08-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Ludwig Boltzmann Institute for Research in Neuromuscular Disorders, Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Exercise Test*
Lactic Acid / blood*
Middle Aged
Mitochondria, Muscle / metabolism,  pathology
Mitochondrial Myopathies / blood,  diagnosis*,  metabolism
Muscle, Skeletal / metabolism,  pathology
Physical Exertion
Time Factors
Reg. No./Substance:
50-21-5/Lactic Acid

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