Document Detail

Lactate provocation of panic attacks in depressed outpatients.
MedLine Citation:
PMID:  3217465     Owner:  NLM     Status:  MEDLINE    
Forty-seven nonmelancholic depressed outpatients were infused with sodium lactate to explore the relationship between history of panic attacks and lactate-induced panic. Lactate panic was rated without knowledge of history of panic. Fifteen of 29 patients (52%) with a history of spontaneous panic experienced panic attacks in response to lactate. Only 1 of 18 patients (6%) without a history of spontaneous panic experienced a lactate-induced panic attack--a highly significant difference. The likelihood of lactate panic was related to frequency of spontaneous panic attacks. The implications of these findings for understanding the relationship of panic attacks and depression are discussed.
P J McGrath; J W Stewart; M R Liebowitz; J M Markowitz; F M Quitkin; D F Klein; J M Gorman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  25     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-03-08     Completed Date:  1989-03-08     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
New York State Psychiatric Institute, NY 10032.
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MeSH Terms
Anxiety Disorders / psychology
Depressive Disorder / psychology*
Fear* / drug effects
Infusions, Intravenous
Lactates / diagnostic use*
Lactic Acid
Middle Aged
Panic* / drug effects
Psychological Tests
Grant Support
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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