Document Detail

Lactate provocation of panic attacks. I. Clinical and behavioral findings.
MedLine Citation:
PMID:  6742978     Owner:  NLM     Status:  MEDLINE    
To assess the pharmacologic and phenomenologic comparability of lactate-induced and naturally occurring panic attacks, patients meeting DSM-III criteria for panic disorder or agoraphobia with panic attacks were infused with 0.5M racemic sodium lactate before and after successful drug treatment. Lactate-induced and naturally occurring panic attacks were symptomatically similar. Following treatment, the patients' response to lactate did not differ from that of normal controls, whereas the pretreatment panic rate was much higher. These data suggest that lactate acts, by as yet unidentified mechanisms, to trigger the same panic attacks as occur spontaneously in vulnerable persons.
M R Liebowitz; A J Fyer; J M Gorman; D Dillon; I L Appleby; G Levy; S Anderson; M Levitt; M Palij; S O Davies
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  41     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-21     Completed Date:  1984-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  764-70     Citation Subset:  AIM; IM    
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MeSH Terms
Agoraphobia / chemically induced,  diagnosis,  drug therapy
Anxiety Disorders / chemically induced*,  diagnosis,  drug therapy
Clonidine / therapeutic use
Desipramine / therapeutic use
Fear* / drug effects
Imipramine / therapeutic use
Lactates* / diagnostic use,  pharmacology
Lactic Acid
Panic* / drug effects
Grant Support
Reg. No./Substance:
0/Lactates; 4205-90-7/Clonidine; 50-21-5/Lactic Acid; 50-47-5/Desipramine; 50-49-7/Imipramine

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