| Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies. | |
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MedLine Citation:
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PMID: 16619130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The nonischemic forearm exercise test (NIFET) has been shown to be as effective as the classic ischemic forearm exercise test (IFET) in the diagnosis of patients with McArdle disease. Recently, the lactate increase normalized to the mechanical energy production in NIFET was suggested to have a intermediate sensitivity and satisfactory specifity for the screening of mitochondrial disorders. METHODS: NIFET at 80% maximal contraction force (MCF) was performed in normal controls (n = 41), patients with mitochondrial disorders (n = 15) and other myopathies (diseased controls, n = 20). 26 healthy volunteers also underwent IFET at 80% MCF. The ratio of lactate increase and workload was defined as specific lactate production (mmol x s/N x l). RESULTS: In normal controls there was no significant different lactate increase during NIFET and IFET. The workload performed showed only a weak significant positive correlation with the lactate increase in the NIFET in normal controls (r(2) = 0.20) but not in IFET and NIFET with patients. A moderate negative correlation of specific lactate production and the absolute workload was found in all groups and in both protocols (r(2) = 0.22-0.34). The specific lactate production was highest in patients with other myopathies, intermediate in patients with mitochondrial disorders and lowest in normal controls. NIFET showed a sensitivity of only 20 % and a specifity of 95% for normal controls, but only 75 % for diseased controls. CONCLUSION: The specific lactate production during NIFET is neither sufficiently specific nor sensitive for the diagnosis of mitochondrial disorders. Increased specific lactate production during rest-to-work transition period might be caused by increased acetyl group deficits. |
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Authors:
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Frank Hanisch; Katharina Eger; Silke Bork; Holger Lehnich; Marcus Deschauer; Stephan Zierz |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-20 |
Journal Detail:
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Title: Journal of neurology Volume: 253 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-29 Completed Date: 2006-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 735-40 Citation Subset: IM |
Affiliation:
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Klinik und Poliklinik für Neurologie, Martin-Luther-Universität, Halle-Wittenberg, Ernst-Grube Strasse 40, 06097 Halle/Saale, Germany. frank.hanisch@medizin.uni-halle.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Analysis of Variance Exercise / physiology* Exercise Test / methods Female Forearm* Humans Lactic Acid / blood* Male Middle Aged Mitochondrial Diseases / blood*, rehabilitation Muscular Diseases / blood*, rehabilitation |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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