Document Detail

Lactate production and catecholamine profile during aerobic exercise in normotensive OSAS patients.
MedLine Citation:
PMID:  15033133     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The aim of the study was to evaluate the catecholaminergic activity and lactate concentration during exercise in normotensive patients with obstructive sleep apnoea syndrome (OSAS). PATIENTS AND METHODS: Thirteen normotensive patients affected by OSAS (mean age+/-standard error (SE), 52.6+/-2.8 yrs; mean apnoea-hypopnea index, 35.7+/-20.3) were enrolled in the study. Night-polysomnography and multiple sleep latency test in the sleep laboratory were performed for every patient. Patients also underwent an incremental workload exercise on a cycloergometer. We evaluated plasma epinephrine and norepinephrine levels in aerobic exercise conditions, relating them to lactate levels. RESULTS: Analysis of the venous lactate curve showed that exercise lactate levels were significantly higher (peak normalised levels, 782 vs. 270%; P<0.001 ), and an earlier lactate threshold was detected, in the patients compared to normal controls. While plasma catecholamine levels were abnormally high in almost all patients at rest, exercise values were not significantly different from controls. Lactate/norepinephrine and lactate/epinephrine area ratios were significantly higher in OSAS subjects than in controls (2.25 vs. 1.21 and 2.37 vs. 1.03, respectively). CONCLUSIONS: The results indicate that abnormal production of lactate during exercise occurs in OSAS, possibly due to some muscular metabolic modification. While catecholaminergic activity is abnormally increased at rest, this activity does not seem to play a significant role in lactate concentration during exercise in these patients.
Enrica Bonanni; Livia Pasquali; Maria Laura Manca; Michelangelo Maestri; Concetta Prontera; Monica Fabbrini; Stefano Berrettini; Giancarlo Zucchelli; Gabriele Siciliano; Luigi Murri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sleep medicine     Volume:  5     ISSN:  1389-9457     ISO Abbreviation:  Sleep Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Neurological Clinic, Department of Neurosciences, University of Pisa, Via Roma 67, Pisa 56126, Italy.
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MeSH Terms
Blood Pressure / physiology*
Catecholamines / metabolism*
Epinephrine / metabolism
Lactic Acid / metabolism*
Middle Aged
Muscle, Skeletal / metabolism
Norepinephrine / metabolism
Positive-Pressure Respiration / methods
Severity of Illness Index
Sleep Apnea, Obstructive / diagnosis,  metabolism*,  therapy
Sleep Stages / physiology
Reg. No./Substance:
0/Catecholamines; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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