Document Detail

Lactate kinetics in severe COPD. Implications of an abnormal aminopyrine breath test.
MedLine Citation:
PMID:  1576848     Owner:  NLM     Status:  MEDLINE    
The ability of the 13C aminopyrine breath test (APBT) to reflect hepatocellular metabolic capacity and therefore to predict lactate removal following incremental exercise in male COPD patients was evaluated. Two previous patients with COPD who had histories of heavy alcohol intake but no overt liver disease showed prolonged lactate elevation following exercise. The possibility of subclinical hepatic disease affecting lactate removal was considered. No patient in the present study had clinical evidence of liver disease. Four of 9 patients had an abnormal APBT (mean 5.0% cumulative dose 13CO2 excreted over 2 h). Patients with a normal APBT (group 1) and with an abnormal APBT (group 2) were compared. The groups did not differ in age or severity of lung disease. An incremental exercise test was performed and lactate samples were collected before, during, and for 90 min following exercise. Exercise parameters (work rate, duration, VO2max, VEmax, and peak lactate) did not differ between groups. Comparing group 1 with group 2 mean values, the time to recover to resting lactate values (Trecov 45 vs 76 min, respectively, p less than 0.005) and the time required for lactate level to return to the normal range (Tnorm 35 vs 65 min, respectively, p less than 0.005) were statistically different. Furthermore, the 2-h excretion of 13CO2 was inversely correlated with both Trecov (r = -0.76, p less than 0.05) and Tnorm (r = -0.79, p less than 0.05). We conclude that subclinical derangement of hepatocellular capacity, as determined by APBT, may adversely affect lactate removal following exercise.
S J Goodnight-White; C C Miller; S E Haber; P D Klein; E C Fletcher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chest     Volume:  101     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-11     Completed Date:  1992-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268S-273S     Citation Subset:  AIM; IM    
Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston.
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MeSH Terms
Aminopyrine / diagnostic use*
Anaerobic Threshold / physiology
Breath Tests / methods
Exercise / physiology
Exercise Test / methods
Lactates / blood*
Lactic Acid
Liver / physiopathology
Lung Diseases, Obstructive / blood*,  physiopathology
Respiratory Function Tests / methods
Time Factors
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 58-15-1/Aminopyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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