| Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts. | |
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MedLine Citation:
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PMID: 10066693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study [G. C. M. Beaufort-Krol, J. Takens, M. C. Molenkamp, G. B. Smid, J. J. Meuzelaar, W. G. Zijlstra, and J. R. G. Kuipers. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1503-H1512, 1998], a lower systemic O2 supply was found in lambs with aortopulmonary left-to-right shunts. To determine whether the lower systemic O2 supply results in increased anaerobic metabolism, we used [1-13C]lactate to investigate lactate kinetics in eight 7-wk-old lambs with shunts and eight control lambs, at rest and during moderate exercise [treadmill; 50% of peak O2 consumption (VO2)]. The mean left-to-right shunt fraction in the shunt lambs was 55 +/- 3% of pulmonary blood flow. Arterial lactate concentrations and the rate of appearance (Ra) and disappearance (Rd) of lactate were similar in shunt and control lambs, both at rest (lactate: 1, 201 +/- 76 vs. 1,214 +/- 151 micromol/l; Ra = Rd: 12.97 +/- 1.71 vs. 12.55 +/- 1.25 micromol. min-1. kg-1) and during a similar relative workload. We found a positive correlation between Ra and systemic blood flow, O2 supply, and VO2 in both groups of lambs. In conclusion, shunt lambs have similar lactate kinetics as do control lambs, both at rest and during moderate exercise at a similar fraction of their peak VO2, despite a lower systemic O2 supply. |
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Authors:
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G C Beaufort-Krol; W G Zijlstra; J Takens; M C Molenkamp; K J Meuzelaar; G B Smid; J R Kuipers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 86 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-07 Completed Date: 1999-05-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 832-9 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Beatrix Children's Hospital, 9700 RB Groningen, The Netherlands. G.C.M.Beaufort@thorax.azg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Aorta / physiology*, surgery Blood Gas Analysis Blood Pressure / physiology Epinephrine / blood Heart Rate / physiology Kinetics Lactic Acid / blood* Norepinephrine / blood Oxygen / blood Physical Exertion / physiology* Pulmonary Artery / physiology*, surgery Pulmonary Circulation / physiology Rest / physiology* Sheep |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7782-44-7/Oxygen |
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