| Lactate infusion in anxiety research: its evolution and practice. | |
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MedLine Citation:
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PMID: 3988715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined. |
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Authors:
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D V Sheehan; D B Carr; S M Fishman; M M Walsh; D Peltier-Saxe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 46 ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-06-12 Completed Date: 1985-06-12 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 158-65 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anxiety Disorders
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blood,
chemically induced*,
psychology Fear / drug effects* Humans Infusions, Parenteral / instrumentation, methods* Lactates / administration & dosage*, blood Lactic Acid Panic / drug effects* Personality Inventory Physical Exertion Psychiatric Status Rating Scales Research Design |
| Grant Support | |
ID/Acronym/Agency:
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PR-1066/PR/OCPHP CDC HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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