Document Detail

Lactate and glucose interactions during rest and exercise in men: effect of exogenous lactate infusion.
MedLine Citation:
PMID:  12411539     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that lactate plays a central role in the distribution of carbohydrate (CHO) potential energy for oxidation and glucose production (GP), we performed a lactate clamp (LC) procedure during rest and moderate intensity exercise. Blood [lactate] was clamped at approximately 4 mM by exogenous lactate infusion. Subjects performed 90 min exercise trials at 65 % of the peak rate of oxygen consumption (V(O(2))(,peak); 65 %), 55 % V(O(2))(,peak) (55 %) and 55 % V(O(2))(,peak) with lactate clamped to the blood [lactate] that was measured at 65 % V(O(2))(,peak) (55 %-LC). Lactate and glucose rates of appearance (R(a)), disappearance (R(d)) and oxidation (R(ox)) were measured with a combination of [3-(13)C]lactate, H(13)CO(3)(-), and [6,6-(2)H(2)]glucose tracers. During rest and exercise, lactate R(a) and R(d) were increased at 55 %-LC compared to 55 %. Glucose R(a) and R(d) were decreased during 55 %-LC compared to 55 %. Lactate R(ox) was increased by LC during exercise (55 %: 6.52 +/- 0.65 and 55 %-LC: 10.01 +/- 0.68 mg kg(-1) min(-1)) which was concurrent with a decrease in glucose oxidation (55 %: 7.64 +/- 0.4 and 55 %-LC: 4.35 +/- 0.31 mg kg(-1) min(-1)). With LC, incorporation of (13)C from tracer lactate into blood glucose (L GNG) increased while both GP and calculated hepatic glycogenolysis (GLY) decreased. Therefore, increased blood [lactate] during moderate intensity exercise increased lactate oxidation, spared blood glucose and decreased glucose production. Further, exogenous lactate infusion did not affect rating of perceived exertion (RPE) during exercise. These results demonstrate that lactate is a useful carbohydrate in times of increased energy demand.
Benjamin F Miller; Jill A Fattor; Kevin A Jacobs; Michael A Horning; Franco Navazio; Michael I Lindinger; George A Brooks
Related Documents :
6853279 - Anaerobic threshold, blood lactate, and muscle metabolites in progressive exercise.
8727539 - Smoking increases conversion of lactate to glucose during submaximal exercise.
21479909 - Myocardial perfusion and exercise capacity 12 years after arterial switch surgery for ...
24094559 - Systolic function reserve using two-dimensional strain imaging in hypertrophic cardiomy...
15531559 - Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fa...
16193339 - Effect of hypercapnia on changes in blood ph, plasma lactate and ammonia due to exercise.
8049809 - Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in a...
10484579 - Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exerc...
6853279 - Anaerobic threshold, blood lactate, and muscle metabolites in progressive exercise.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  544     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-05-01     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  963-75     Citation Subset:  IM    
Department of Integrative Biology, University of California, Berkeley 94720, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism*
Energy Metabolism
Exercise / physiology*
Glycogen / metabolism
Heart / physiology
Lactic Acid / blood,  metabolism*,  pharmacology
Liver / metabolism
Osmolar Concentration
Oxygen Consumption
Reference Values
Rest / physiology
Grant Support
Reg. No./Substance:
0/Blood Glucose; 50-21-5/Lactic Acid; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exercise induces hepatosplanchnic release of heat shock protein 72 in humans.
Next Document:  Arm blood flow and metabolism during arm and combined arm and leg exercise in humans.