Document Detail


Lactate and glucose interactions during rest and exercise in men: effect of exogenous lactate infusion.
MedLine Citation:
PMID:  12411539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that lactate plays a central role in the distribution of carbohydrate (CHO) potential energy for oxidation and glucose production (GP), we performed a lactate clamp (LC) procedure during rest and moderate intensity exercise. Blood [lactate] was clamped at approximately 4 mM by exogenous lactate infusion. Subjects performed 90 min exercise trials at 65 % of the peak rate of oxygen consumption (V(O(2))(,peak); 65 %), 55 % V(O(2))(,peak) (55 %) and 55 % V(O(2))(,peak) with lactate clamped to the blood [lactate] that was measured at 65 % V(O(2))(,peak) (55 %-LC). Lactate and glucose rates of appearance (R(a)), disappearance (R(d)) and oxidation (R(ox)) were measured with a combination of [3-(13)C]lactate, H(13)CO(3)(-), and [6,6-(2)H(2)]glucose tracers. During rest and exercise, lactate R(a) and R(d) were increased at 55 %-LC compared to 55 %. Glucose R(a) and R(d) were decreased during 55 %-LC compared to 55 %. Lactate R(ox) was increased by LC during exercise (55 %: 6.52 +/- 0.65 and 55 %-LC: 10.01 +/- 0.68 mg kg(-1) min(-1)) which was concurrent with a decrease in glucose oxidation (55 %: 7.64 +/- 0.4 and 55 %-LC: 4.35 +/- 0.31 mg kg(-1) min(-1)). With LC, incorporation of (13)C from tracer lactate into blood glucose (L GNG) increased while both GP and calculated hepatic glycogenolysis (GLY) decreased. Therefore, increased blood [lactate] during moderate intensity exercise increased lactate oxidation, spared blood glucose and decreased glucose production. Further, exogenous lactate infusion did not affect rating of perceived exertion (RPE) during exercise. These results demonstrate that lactate is a useful carbohydrate in times of increased energy demand.
Authors:
Benjamin F Miller; Jill A Fattor; Kevin A Jacobs; Michael A Horning; Franco Navazio; Michael I Lindinger; George A Brooks
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  544     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-05-01     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  963-75     Citation Subset:  IM    
Affiliation:
Department of Integrative Biology, University of California, Berkeley 94720, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Energy Metabolism
Exercise / physiology*
Gluconeogenesis
Glycogen / metabolism
Heart / physiology
Humans
Kinetics
Lactic Acid / blood,  metabolism*,  pharmacology
Liver / metabolism
Male
Osmolar Concentration
Oxidation-Reduction
Oxygen Consumption
Reference Values
Respiration
Rest / physiology
Grant Support
ID/Acronym/Agency:
AR-42906/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 50-21-5/Lactic Acid; 9005-79-2/Glycogen
Comments/Corrections

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