| Lactate fuels the human brain during exercise. | |
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MedLine Citation:
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PMID: 18653766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human brain releases a small amount of lactate at rest, and even an increase in arterial blood lactate during anesthesia does not provoke a net cerebral lactate uptake. However, during cerebral activation associated with exercise involving a marked increase in plasma lactate, the brain takes up lactate in proportion to the arterial concentration. Cerebral lactate uptake, together with glucose uptake, is larger than the uptake accounted for by the concomitant O(2) uptake, as reflected by the decrease in cerebral metabolic ratio (CMR) [the cerebral molar uptake ratio O(2)/(glucose+(1/2) lactate)] from a resting value of 6 to <2. The CMR also decreases when plasma lactate is not increased, as during prolonged exercise, cerebral activation associated with mental activity, or exposure to a stressful situation. The CMR decrease is prevented with combined beta(1)- and beta(2)-adrenergic receptor blockade but not with beta(1)-adrenergic blockade alone. Also, CMR decreases in response to epinephrine, suggesting that a beta(2)-adrenergic receptor mechanism enhances glucose and perhaps lactate transport across the blood-brain barrier. The pattern of CMR decrease under various forms of brain activation suggests that lactate may partially replace glucose as a substrate for oxidation. Thus, the notion of the human brain as an obligatory glucose consumer is not without exceptions. |
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Authors:
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Bjørn Quistorff; Niels H Secher; Johannes J Van Lieshout |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-07-24 |
Journal Detail:
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Title: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 22 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 3443-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobiosis Brain / metabolism* Exercise* Glucose / metabolism Humans Lactic Acid / metabolism* Oxygen / metabolism |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 50-99-7/Glucose; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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