| Lactate concentrations in the rectal lumen in patients in early septic shock. | |
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MedLine Citation:
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PMID: 20560883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previously, we observed that rectal luminal lactate was higher in non-survivors compared with survivors of severe sepsis or septic shock persisting >24 h. The present study was initiated to further investigate this tentative association between rectal luminal lactate and mortality in a larger population of patients in early septic shock. METHODS: A prospective observational multicentre study of 130 patients with septic shock at six general ICU's of university hospitals. Six to 24 h after the onset of septic shock, the concentration of lactate in the rectal lumen was estimated by a 4-h equilibrium dialysis. Dialysate concentrations of lactate were determined using an auto-analyser. RESULTS: The overall 30-day mortality was 32%, with age and Simplified acute physiology scores II and sequential organ failure assessment scores being significantly higher in non-survivors. In contrast, there were no differences in concentrations of lactate in the rectal lumen [2.2 (1.4-4.1) and 2.8 (1.6-5.1) mmol/l (P=0.34)] (medians and 25th-75th percentiles) or arterial blood [2.1 (1.4-4.2) and 2.0 (1.3-3.2) mmol/l (P=0.15)] between non-survivors and survivors. The rectal-arterial difference of the lactate concentration was higher in survivors. There were no differences in blood pressure, noradrenaline dose or central venous oxygen saturation between the groups. CONCLUSION: In this prospective, observational study of unselected patients with early septic shock, there was no difference in the concentration of lactate in the rectal lumen between non-survivors and survivors. TRIAL REGISTRATION: Clinicaltrials.gov (no: NCT00197938). |
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Authors:
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M Ibsen; J Tenhunen; J Wiis; T Waldau; A Ø Lauritsen; K Thornberg; H Joensen; A Perner |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-06-15 |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 54 ISSN: 1399-6576 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 827-32 Citation Subset: IM |
Affiliation:
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Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. micibs@dadlnet.dk |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00197938 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Blood Pressure / physiology Cohort Studies Dialysis Female Humans Lactic Acid / metabolism* Male Middle Aged Norepinephrine / therapeutic use Oxygen / blood Predictive Value of Tests Prospective Studies Rectum / metabolism* Shock, Septic / metabolism*, mortality Survival Treatment Outcome Vasoconstrictor Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Vasoconstrictor Agents; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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