Document Detail

Lactate, N-acetylaspartate, choline and creatine concentrations, and spin-spin relaxation in thalamic and occipito-parietal regions of developing human brain.
MedLine Citation:
PMID:  8946353     Owner:  NLM     Status:  MEDLINE    
Previous studies of the brains of normal infants demonstrated lower lactate (Lac)/choline (Cho), Lac/creatine (Cr), and Lac/ N-acetylaspartate (Naa) peak-area ratios in the thalamic region (predominantly gray matter) compared with occipitoparietal (mainly unmyelinated white matter) values. In the present study, thalamic Cho, Cr, and Naa concentrations between 32-42 weeks' gestational plus postnatal age were greater than occipito-parietal: 4.6 +/- 0.8 (mean +/- SE), 10.5 +/- 2.0, and 9.0 +/- 0.7 versus 1.8 +/- 0.6, 5.8 +/- 1.5, and 3.4 +/- 1.1 mmol/kg wet weight, respectively: Lac concentrations were similar, 2.7 +/- 0.6 and 3.3 +/- 1.3 mmol/kg wet weight, respectively. In the thalamic region, Cho and Naa T2s increased, and Cho and Lac concentrations decreased, during development. Lower thalamic Lac peak-area ratios are principally due to higher thalamic concentrations of Cho, Cr, and Naa rather than less Lac. The high thalamic Cho concentration may relate to active myelination; the high thalamic Naa concentration may be due to advanced gray-matter development including active myelination. Lac concentration is higher in neonatal than in adult brain.
E B Cady; J Penrice; P N Amess; A Lorek; M Wylezinska; R F Aldridge; F Franconi; J S Wyatt; E O Reynolds
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  36     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-25     Completed Date:  1997-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  878-86     Citation Subset:  IM    
Department of Medical Physics and Bioengineering, University College London Hospitals, United Kingdom.
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MeSH Terms
Aspartic Acid / analogs & derivatives*,  analysis
Brain Chemistry*
Choline / analysis*
Creatine / analysis*
Gestational Age
Infant, Newborn
Lactic Acid / analysis*
Magnetic Resonance Spectroscopy / methods
Occipital Lobe / chemistry,  growth & development
Parietal Lobe / chemistry,  growth & development
Sensitivity and Specificity
Thalamus / chemistry,  growth & development
Reg. No./Substance:
50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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