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Lactate Dehydrogenase In Hypothermia Treated Newborn Infants With Hypoxic Ischemic Encephalopathy.
MedLine Citation:
PMID:  22775455     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims:  We investigated whether plasma lactate dehydrogenase (LDH) predicts outcome in hypothermia (HT) treated term infants with moderate/severe hypoxic-ischaemic encephalopathy (HIE) and additionally whether LDH differs between infants with evidence for acute and non-acute perinatal insults and postnatal collapse (PNC). Methods:  Data from HT treated infants with HIE (n=39) were analyzed retrospectively. Adverse outcome was defined as a Mental and/or Psychomotor Developmental Index (Bayley Scales of Infant Development II), at 18 months <70. The likely timing of insult onset was assessed in infants with an LDH sample obtained within 6h of birth or PNC (n=20). Results:  LDH differed between the favourable/adverse outcome groups at the end of HT treatment (median (IQR) 1540 (1400-1950)U/L vs. 3555 (3003-8705)U/L, (p<0.01)). All infants (n=22) with LDH <2085U/L had a favourable outcome while 6 of 11 infants with LDH≥2085U/L had an adverse outcome. LDH in those who died (n=4) was higher than the favourable outcome group (5090 (2915-12222)U/L, (p<0.01) but sampled earlier. Early LDH differed significantly (p<0.01) between infants with evidence for acute or non-acute insults or PNC. Conclusion:  These results offer a biomarker, with high negative predictive value in the assessment of outcome in HT treated term infants, needing prospective validation. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Authors:
Marianne Thoresen; Xun Liu; Sally Jary; Emma Brown; Hemmen Sabir; Janet Stone; Frances Cowan; Mathias Karlsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-7
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta P&aelig;diatrica © 2012 Foundation Acta P&aelig;diatrica.
Affiliation:
School of Clinical Sciences, University of Bristol, Bristol, United Kingdom University Hospital Bristol, Department of Biochemistry Department of Clinical Science and Education, Karolinska Institute at Stockholm Söder Hospital Department of Paediatrics, Imperial College, Hammersmith Hospital, London, United Kingdom Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
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