Document Detail


Lactate Dehydrogenase As An Indicator Of Severe Illness In Neonatal Intensive Care Patients: A Longitudinal Cohort Study.
MedLine Citation:
PMID:  22963670     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  Lactate dehydrogenase (LDH) increases in several critical conditions that cause cell damage and could potentially be used for early detection of serious illness in the newborn. Our aim was to investigate the relationship between the early clinical course of NICU infants and LDH in plasma at admission. Methods:  LDH was measured in a cohort of patients consecutively admitted to a major NICU in Hanoi. The infants were classified as "obviously needing intensive care during the first week" (n=83) or "not receiving intensive care measures during the first week" (n=260) by a senior neonatologist blinded to the LDH and lactate activity. Results:  LDH differed significantly between the groups in infants born after 32 gestational weeks. LDH differed with the vitality of the patient (F=26.25, p<0.0001) at admittance and correlated with lactate (R=0.496, p<0.0001). Also, the predictive value for obvious need of intensive care was higher for LDH than for lactate assessed by area under the curve calculated with ROC-curves (0.82 (0.77-0.88) vs. 0.67 (0.60-0.75)). Conclusion:  There is a strong relationship between bad clinical condition of infants during first week of life and elevated plasma LDH. The results suggest that LDH might be a valuable support in decision making in the neonatal period. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Authors:
Mathias Karlsson; Khu Thi Khanh Dung; Truong Le Thi; Erik Borgström; Karin Jonstam; Lovisa Kasström; Birger Winbladh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-11
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Affiliation:
Department of Clinical Science and Education, Karolinska Institute at Stockholm Söder Hospital Department of Clinical research, Karlstad, Sweden National Hospital of Pediatrics, Hanoi, Vietnam.
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