| Lactase Deficiency: A Potential Novel Aetiological Factor in Chronic Pruritus of Unknown Origin. | |
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MedLine Citation:
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PMID: 21879247 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic pruritus, which is associated with a wide variety of underlying diseases, represents a challenge in diagnostics and treatment in dermatology and general medicine. The cause of pruritus remains unknown in up to 45% of patients. In this study, 718 patients with chronic pruritus were analysed concerning lactase deficiency, demographic data, aetiology, duration and intensity of pruritus. A total of 154 patients were tested positive for lactase deficiency and 38.3% showed a significant anti-pruritic response to a lactose-free diet (minimum 4 weeks). The best results were observed in patients with pruritus of mixed or unknown origin (n = 91; 64% response). Age, sex, localization or duration had no significant influence on the anti-pruritic effect of a lactose-free diet. Lactase deficiency might be an independent causal factor in the elicitation of chronic pruritus. Thus, screening for lactase deficiency represents a rational step in the diagnostic work-up of chronic pruritus. In case of a positive test result, a lactose-free diet offers a low-cost, efficient and specific therapy in patients with chronic pruritus. |
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Authors:
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Sonja A Grundmann; Ewelina Stratmann; Randolf Brehler; Thomas A Luger; Sonja Ständer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
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Title: Acta dermato-venereologica Volume: - ISSN: 0001-5555 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology and Competence Center Chronic Pruritus, University Hospital, DE-48149 Münster, Germany. E-mail: sonja.grundmann@ukmuenster.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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