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Lacrimal gland involvement in lymphomatoid granulomatosis and review of the literature.
MedLine Citation:
PMID:  20871660     Owner:  NLM     Status:  In-Data-Review    
Objective. To describe the clinicoradiological and histopathological findings in a case of lacrimal gland enlargement secondary to lymphomatoid granulomatosis (LG) and to review the literature. Design. Case report and systematic literature review. Methods. A 75-year-old woman presented with right ptosis. Computerised tomography showed lacrimal gland enlargement, and biopsy done was inconclusive. She subsequently developed pulmonary symptoms and underwent transbronchial biopsy that was diagnosed as LG. Pub Med and OVID databases were searched using the term "orbit/eye involvement in lymphomatoid granulomatosis". Articles that predated the databases were gathered from current references. Results. The patient underwent lacrimal gland biopsy which revealed necrotic and inflamed tissue with no further categorisation but transbronchial biopsy helped in establishing the diagnosis of LG. On initiation of prednisolone and cyclophosphamide, her orbital lesion resolved but the patient died following massive pulmonary hemorrhage within a month of diagnosis. Conclusion. Ophthalmic involvement in LG is very rare. Varied presentations are due to central nervous system involvement, vasculitis, or infiltration of ocular or orbital structures. LG is an angiocentric and angiodestructive granulomatous disorder and can involve any tissue, thus accounting for the variable presentations reported in literature.
Thanuja Gopal Pradeep; Paul Cannon; Thomas Dodd; Dinesh Selva
Publication Detail:
Type:  Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Journal of ophthalmology     Volume:  2010     ISSN:  2090-0058     ISO Abbreviation:  J Ophthalmol     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101524199     Medline TA:  J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, SA 5000, Australia.
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